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Denver Broncos 21–17 Philadelphia Eagles

Bo Nix connected with a short scoring throw and the running back added a two-yard rushing score in the fourth quarter as the Denver Broncos erased a two-touchdown disadvantage to deliver the Eagles their initial defeat of the season. Denver's defense deflected Jalen Hurts' final pass on the game's concluding play to hand the reigning title holders to just their second loss in their last 22 games. Denver (3-2) caught a huge break in their comeback when the Philadelphia had a crucial play called back on a formation infraction whistled against running back Saquon Barkley.

Texans Dominate Depleted Ravens in Record Win

CJ Stroud passed for 244 yards and four touchdowns, and Houston (2-3) cruised to a 44-10 win over a depleted Baltimore team, equaling both the most lopsided road win in Texans' history and the most lopsided home loss in Ravens' history. Baltimore (one win and four losses) were missing two-time MVP quarterback Lamar Jackson, and that was not their only problem. Defensive standouts Kyle Hamilton, Roquan Smith and Marlon Humphrey all were absent, and the Ravens already were weakened on defense because of a cervical issue that ended the defensive lineman's campaign. The Ravens were also without Pro Bowl blocker Ricard and tackle Ronnie Stanley.

Colts Rout Raiders in One-Sided Affair

Jonathan Taylor scored three rushing scores and a two-pointer, and Daniel Jones threw two touchdown passes as the Indianapolis Colts overwhelmed the Raiders. The 34-point margin was Indianapolis' biggest since 2013. Jones completed 20 passes out of 29 attempts for 212 passing yards and improved to four wins and one loss as a starter this season, exceeding his combined victory total over the past two seasons with the New York Giants. Taylor carried 17 times for 66 yards and caught three receptions for 20 receiving yards. Indianapolis turned multiple takeaways into touchdowns. The Raiders dropped to four wins and one loss.

Dallas Cowboys 37-22 New York Jets

Dallas' quarterback threw four touchdown passes, leading the Dallas Cowboys to a comfortable win over the New York Jets. The Cowboys scored on two 90-yard drives in the second quarter, despite being without four starters on the offensive line. The running back gained 135 yards and a score and also caught a receiving touchdown. The Cowboys, now 2-2-1, bounced back from a high-scoring draw against the Packers last week. The Jets are still without a victory at 0-5 in their new coach's first season as head coach.

Minnesota Vikings 21–17 Cleveland Browns

Minnesota wideout Addison grabbed a 12-yard touchdown pass from Carson Wentz with under half a minute remaining to secure the Vikings a win over the Browns at London's Tottenham Hotspur Stadium. This methodical march gave the Minnesota (3-2) a crucial victory on their historic international road trip, which started with a narrow defeat to the Steelers in Dublin last week. This also marred the rookie's debut as starter, as the Browns rookie put his team (one win and four losses) in contention by throwing two touchdown passes. Fellow rookie Judkins gained 110 yards on 23 carries. The quarterback shook off an arm issue that briefly sent him to the locker room and led two scoring drives in the latter half.

Panthers Stage Epic Comeback Against Dolphins

Carolina's quarterback threw for two touchdowns and the running back ran for 206 rushing yards and a score as the Panthers came back against the Dolphins in their home stadium. The quarterback's quick throw to the first-year receiver with under two minutes to play gave the Panthers (two wins and three losses) the lead for good as they equaled the largest comeback to win a game in franchise history by erasing a large deficit. Young had a poor start, but he finished 19-for-30 passing for 198 passing yards with an interception. Dowdle, replacing injured Chuba Hubbard, did his damage on the run on 23 carries, falling just short of matching the team's all-time rushing mark. Miami's Tua Tagovailoa threw 27 of 36 for 256 yards with three scores and Jaylen Waddle accumulated 110 yards through the air on six catches and scored a score, but the Dolphins (one win and four losses) fell to zero wins and three losses in road games.

Saints Secure First Win Under New Coach

Spencer Rattler passed for a long touchdown to Rashid Shaheed, safety Jordan Howden returned a fumble the length of the field for a score, and New Orleans beat the error-prone Giants for the Saints' first victory under first-year head coach Moore. The QB earned his first victory in 11 career starts, passing for 225 yards without any mistakes. Giants rookie QB Dart, who won his debut last week, threw for 202 yards and two touchdowns, but also committed errors three times. New York gave up possession five times in all, with none worse than when Bryan Bresee stripped ball carrier Skattebo, leading to the safety's TD. Each squad are one win and four losses.